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COQ10

CoQ10 and senescent cell inhibition Increasing evidence indicates that reactive oxygen species are the main factor promoting stem cell aging. Recent studies have demonstrated that coenzyme Q10 (CoQ10) plays a positive role in the inhibition of organ and cellular aging. CoQ10 is shown to protect stem cell aging the mechanisms of cell senescence inhibited by CoQ10 are being studied by scientists. Ref
Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells through mTOR Signaling. Ref

Fucoidan

Fucoidan Rescues p-Cresol-Induced Cellular Senescence in Mesenchymal Stem Cells and increased proliferation through the regulation of cell cycle-associated proteins (CDK2, CDK4, cyclin D1, and cyclin E). Ref
Fucoidan,  found in brown algae and seaweed displays a variety of biological activities, including anti-senescence, anti-apoptotic, anti-tumor, anti-inflammatory, and anti-oxidative functions. Fucoidan improved endothelial progenitor cells (Stem cells) bioavailability and increased cell numbers and their functional properties. Ref
Fucoidan has been reported to induce the differentiation and mineralization of osteoblastic cells (bone stem cells). Ref Fucoidan ingestion increases the expression of CXCR4 on human CD34+ cells. Hematopoietic progenitor stem cells (HPC) are an important treatment modality for a variety of neoplastic diseases. Following ingestion of fucoidan, CD34(+) cells increased significantly. Oral fucoidan significantly amplified the CXCR4(+) HPC population. The proportion of CD34(+) cells that expressed CXCR4 increased from 45% to 90% after 12 days. Ref